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Real-time continuous monitoring of cerebral blood flow auto-regulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass. The cell types of the deep (hematoxylin-staining) portion of thefundic mucosa are considered in the bottom figure. Optimal pharmaco-logic treatment has not been established.

Prior sensitization is needed and a latentperiod of at least 1–2 weeks is required afterthe first exposure.